Dune: Chronicles of the Imperium (2000)

From the back of the book:
Experience the splendor... the danger... the intrigue of DUNE, as you and your friends step into the roles of House Mentats, Swordmasters, Nobles, and Bene Gesserit Sisters in service to one of the Great Houses of the Landsraad. Stride across the scorching sands of Arrakis or finesse your way into an imperial gala on Wallach IX. Smuggle the spice melange to the rich and powerful, or lead your House's forces in a razzia against the Harkonnen oppressors. Endless adventure lies ahead!

Dune: Chronicles of the Imperium (2000): Last Unicorn Games; role-playing game set in the Dune universe. Delayed by legal issues and then a corporate buy-out of Last Unicorn by Wizards of the Coast, a "Limited Edition" run of 3000 copies of a core rule-book was initially published, pending Wizard of the Coast's conversion of the game to its d20 role-playing game system and a subsequent wider release. The company later announced that the game would be discontinued.

Source: http://en.wikipedia.org/wiki/List_of_Dune_games