From the Smallville RPG:
The rules as a whole are known as the Cortex Plus System, and they're a variation on a set of rules used in other games published by Margaret Weis Productions. Cortex uses dice of various sizes, from four-sides to twelve-sides, and a primary focus is using the rules to help players tell dramatic and interesting stories. It's called Cortex Plus because...there are even more twists and tweaks than before.
User Summary:
When MWP switched lead designers (from Jamie Chambers to Cam Banks), the Cortex system morphed into the Cortex Plus system. The system logo changed (adding the Plus). Much of the terminology stayed the same (Plot Points, Complications, Traits, and the various die types), but the mechanics changed drastically from the very traditional Cortex to the very narrative Cortex Plus.