From the Introduction:
Although Dr Alphonse Moreau perished on Noble's Isle
sometime in late 1887, his work did not. In 1891, an expedition
was sent by the British government to salvage what they could
and return any papers or specimens that were still alive.
Although the expedition was publicly reported as a failure, it
did succeed in bringing back enough information for scientists
to replicate Dr Moreau's work - the surgical hybridisation of
Man and Beast.
A small laboratory was established somewhere in the bucolic
conutryside of England. The scientists at the laboratory
successully reproduced all of Moreau's techniques and added
page after page to their new bestiary. The new creations were
studied, both physically and mentally, to see what use they
could be in the new century.
In "His is the Hand", the players take the part of the Beast-Men:
hybrids created from the legacy of Dr Moreau.