The world is uninhabited except for one huge city called Nexus. Nexus is run by clans, which are mostly comprised of Vampires. Most Humans are "cattle" for these Vampires, but some intelligent Humans do exist, and struggle to fit into a Vampire run society.
Relations between the intelligent Humans and Vampires are tense at best, though Humans are allowed to live in the city and do business.
Businesses both small and large litter Nexus, the most prominent of these being the 7 major corporations.
Nexus is a microcosm of our world, with all the technology, entertainment, and objects that you know from the real world. Players can purchase things from a Sears catalog, for example, or buy food from a McDonalds menu at McDonalds prices.