From the first page of the PDF:
The nation of Cormyr calls upon the power of the Five Companies, but there is a price for this newly forged alliance. Adventurers must travel to the very Pillars of Creation and retrieve artifacts stolen by the treacherous Seric Vargenos. A Living Forgotten Realms adventure set in the Elemental Chaos for characters of the Paragon tier (levels 11-20).
This adventure happens at roughly the same time (in-game) as SPEC5-3, and after the events of ADCP5‒1. The events of this adventure have a direct impact on the Battle Interactive ADCP5-2 Best Defense (although you do not have to play the BI to get the full benefits from this adventure, and the story is self-contained).