Being built upon the foundation of Dungeons & Dragons 5E rules means that the science fiction of HYPERLANES can easily play nice with the fantasy of the source material. This can be as simple a matter of adopting small elements, or as great as pulling in whole systems in a pinch. HYPERLANES is another tool in the toolbox of Dungeon Masters, and one that can be used however you see fit. You can easily shave off the serial numbers on a monster, spell, or magic item from officially published material and deploy it wherever you wish. A creative DM can even go so far as to take published adventure modules and rename the places and characters, making them into quick and dirty sci-fi encounters.