From the introduction:
On the island of Hawaii, a broken family lives. Six year old Lilo and nineteen year old Nani were not long ago orphaned, when their parents died in a car crash. This has isolated Lilo from people her own age, and she finds herself unable to make friends, often acting out.
Above earth a mad scientist is on trial by the Galactic Federation, for the creation of genetic experiments. These experiments are small creatures with an assortment of powers.