From the introduction:
The 1-2-3 Cthulhu role-playing game is set in a modern world of supernatural horror, science fiction and insanity, with a touch of tragic comedy. It was heavily inspired from the game Call of Cthulhu, based on the writings of H.P. Lovecraft. Think of a mixture of The X Files, Edgar Allan Poe, Ghost Busters, The Twilight Zone, Scooby Do, zombie movies, ghost stories, H.G. Wells, Buffy and Ringu.
In 1-2-3 Cthulhu, you play a group of investigators in paranormal phenomena. It is a world where you may encounter strange creatures of the night, ancient spirits and godlike creatures from outer space – a world of occult magick, weird science and horrific dimensions of space-time the human mind is too fragile to understand.