From the back cover:
Man Dies Three Times in One Night!
A puzzling headline begins a front-page article found in the Times of London. Three men, all identical in identification, were found in the same room of the Chelsea Arms. All were dispatched in the same manner - stabbed through the heart.
Then the home of a valued friend burns to the ground, severely burning him in the process. An odd summons, a surreptitious meeting, and a thousand-mile journey begins on the legendary rail service carrying the investigators to the Gateway of the Orient.
Orient Express contains a massive adventure for the Call of Cthulhu roleplaying game. Beginning in 1920s London, the investigators journey to Paris and thence to the ancient city of Constantinople. With luck, they may also return home. Four books are contained within, Through the Alps, Italy and Eastern Europe, Constantinople & Return, and Strangers On The Train. In addition there are numerous player handouts: a European route map; luggage stickers; scrolls; passports; 25mm cardstock plans of the train that can be laid end-to-end; and fragments of an ancient artifact collected along the way.