Up to three simultaneous players control the monsters George (a King Kong-like gorilla), Lizzy (a Godzilla-like dinosaur), or Ralph (a giant werewolf), created from humans who were mutated by experiments conducted at Scumlabs. They need to destroy all buildings in a high-rise city to advance to the next city. On their way they can destroy helicopters, tanks, taxis, police cars, boats, and trolleys, as well as eat people.
Source: Wikipedia, "Rampage World Tour", available under the CC-BY-SA License.