Area 51 is a 2005 first-person shooter survival horror video game developed by Midway Studios Austin and published by Midway for the PlayStation 2, Xbox, and Microsoft Windows, and is a loose remake of the 1995 light gun video game of the same name. Players control Ethan Cole, a HazMat operative voiced by David Duchovny sent to the infamous base to investigate some manner of viral outbreak.
Area 51 at first starts out with intense combat where the player has several AI teammates with him (ranging from two to seven most of the time) versus hordes of mutants. Notable among the voice actors are David Duchovny (as Ethan Cole), Marilyn Manson (as Edgar the ancient and powerful Grey), Powers Boothe (as Major Bridges), and Ian Abercrombie (as Dr. Cray).
Source: Wikipedia, "Area 51 (2005 video game)", available under the CC-BY-SA License.